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Can Selenoenzymes Resist Electrophilic Modification? Evidence from Thioredoxin Reductase and a Mutant Containing α-Methylselenocysteine.

Biochemistry - 15 Sept 2020

Ste Marie Emma J, Wehrle Robert J, Haupt Daniel J, Wood Neil B, van der Vliet Albert, Previs Michael J, Masterson Douglas S, Hondal Robert J

Abstract excerpt

Selenocysteine (Sec) is the 21st proteogenic amino acid in the genetic code. Incorporation of Sec into proteins is a complex and bioenergetically costly process that evokes the following question: "Why did nature choose selenium?" An answer that has emerged over the past decade is that Sec confers resistance to irreversible oxidative inactivation by reactive oxygen species. Here, we explore the question of...

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Identifiers

PMID: 32845139
DOI: 10.1021/acs.biochem.0c00608
PMCID: PMC7509987

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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