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PRDX6 contributes to selenocysteine metabolism and ferroptosis resistance

14 Nov 2024

Abstract excerpt

Selenocysteine (Sec) metabolism is crucial for cellular function and ferroptosis prevention and begins with the uptake of the Sec carrier, selenoprotein P (SELENOP). Following uptake, Sec released from SELENOP is metabolized via selenocysteine lyase (SCLY), producing selenide, a substrate for selenophosphate synthetase 2 (SEPHS2), which provides the essential selenium donor, selenophosphate (H 2 SePO 3 − ), for...

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PMID: 39547224
DOI: 10.1016/j.molcel.2024.10.027

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