Article
Genome-wide association analyses of breast cancer in women of African ancestry identify new susceptibility loci and improve risk prediction.
Nature genetics - 1 May 2024
Jia Guochong, Ping Jie, Guo Xingyi, Yang Yaohua, Tao Ran, Li Bingshan, Ambs Stefan, Barnard Mollie E, Chen Yu, Garcia-Closas Montserrat, Gu Jian, Hu Jennifer J, Huo Dezheng, John Esther M, Li Christopher I, Li James L, Nathanson Katherine L, Nemesure Barbara, Olopade Olufunmilayo I, Pal Tuya, Press Michael F, Sanderson Maureen, Sandler Dale P, Shu Xiao-Ou, Troester Melissa A, Yao Song, Adejumo Prisca O, Ahearn Thomas, Brewster Abenaa M, Hennis Anselm J M, Makumbi Timothy, Ndom Paul, O'Brien Katie M, Olshan Andrew F, Oluwasanu Mojisola M, Reid Sonya, Butler Ebonee N, Huang Maosheng, Ntekim Atara, Qian Huijun, Zhang Haoyu, Ambrosone Christine B, Cai Qiuyin, Long Jirong, Palmer Julie R, Haiman Christopher A, Zheng Wei
Abstract excerpt
We performed genome-wide association studies of breast cancer including 18,034 cases and 22,104 controls of African ancestry. Genetic variants at 12 loci were associated with breast cancer risk (P < 5 × 10-8), including associations of a low-frequency missense variant rs61751053 in ARHGEF38 with overall breast cancer (odds ratio (OR) = 1.48) and a common variant rs76664032 at chromosome 2q14.2 with...