Article
The aberrant expression of stimulatory and inhibitory killer immunoglobulin-like receptors in NK- and NKT-cells contributes to lupus.
Clinical laboratory - 1 Jan 2014
Bai Yanyan, Zhang Yuanchao, Yang Qingrui, Hou Yanfeng, Hu Naiwen, Wang Dong, Sun Hongsheng
Abstract excerpt
BACKGROUND: Killer cell immunoglobulin-like receptors (KIR) contribute to the pathogenesis of multiple auto-immune diseases via the modulation of NK-, NKT- and T-cells. Thus, we want to know whether the expression pattern of KIR is associated with systemic lupus erythematosus (SLE) susceptibility. METHODS: Here, real-time quantitative PCR and fluorescence-activated cell sorting (FACS) were used to measure the...
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