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Article

FBXW7 mutations in melanoma and a new therapeutic paradigm.

Journal of the National Cancer Institute - 1 Jun 2014

Aydin Iraz T, Melamed Rachel D, Adams Sarah J, Castillo-Martin Mireia, Demir Ahu, Bryk Diana, Brunner Georg, Cordon-Cardo Carlos, Osman Iman, Rabadan Raul, Celebi Julide Tok

Abstract excerpt

BACKGROUND: Melanoma is a heterogeneous tumor with subgroups requiring distinct therapeutic strategies. Genetic dissection of melanoma subgroups and identification of therapeutic agents are of great interest in the field. These efforts will ultimately lead to treatment strategies, likely combinatorial, based on genetic information. METHODS: To identify "driver" genes that can be targeted therapeutically, we...

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PMID: 24838835
DOI: 10.1093/jnci/dju107
PMCID: PMC4081626

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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