Article
Methods for Molecular Diagnosis of Human Prion Disease.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2017
Wadsworth Jonathan D F, Adamson Gary, Joiner Susan, Brock Lara, Powell Caroline, Linehan Jacqueline M, Beck Jonathan A, Brandner Sebastian, Mead Simon, Collinge John
Abstract excerpt
Human prion diseases are associated with a range of clinical presentations, and they are classified by both clinicopathological syndrome and etiology, with subclassification according to molecular criteria. Here, we describe updated procedures that are currently used within the MRC Prion Unit at UCL to determine a molecular diagnosis of human prion disease. Sequencing of the PRNP open reading frame to establish...
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