Article
Genetic risk factors for variant Creutzfeldt-Jakob disease: a genome-wide association study.
The Lancet. Neurology - 1 Jan 2009
Mead Simon, Poulter Mark, Uphill James, Beck John, Whitfield Jerome, Webb Thomas E F, Campbell Tracy, Adamson Gary, Deriziotis Pelagia, Tabrizi Sarah J, Hummerich Holger, Verzilli Claudio, Alpers Michael P, Whittaker John C, Collinge John
Abstract excerpt
BACKGROUND: Human and animal prion diseases are under genetic control, but apart from PRNP (the gene that encodes the prion protein), we understand little about human susceptibility to bovine spongiform encephalopathy (BSE) prions, the causal agent of variant Creutzfeldt-Jakob disease (vCJD). METHODS: We did a genome-wide association study of the risk of vCJD and tested for replication of our findings in samples...
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