Article
Enhanced circadian phase resetting in R192Q Cav2.1 calcium channel migraine mice.
Annals of neurology - 1 Sept 2008
van Oosterhout Floor, Michel Stephan, Deboer Tom, Houben Thijs, van de Ven Rob C G, Albus Henk, Westerhout Joost, Vansteensel Mariska J, Ferrari Michel D, van den Maagdenberg Arn M J M, Meijer Johanna H
Abstract excerpt
OBJECTIVE: Mammalian circadian rhythms are driven by the circadian pacemaker of the suprachiasmatic nucleus (SCN) and are synchronized to the external 24-hour light/dark cycle. After advance time zone transitions (eastbound jet lag), overt circadian rhythms require several days to adjust. The retarded adaptation may protect against acute imbalance of different brain systems. Abrupt circadian rhythm changes may...
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