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Endothelial Protein C Receptor Function in Murine and Human Breast Cancer Development

9 Apr 2013

Abstract excerpt

Several markers identify cancer stem cell-like populations, but little is known about the functional roles of stem cell surface receptors in tumor progression. Here, we show that the endothelial protein C receptor (EPCR), a stem cell marker in hematopoietic, neuronal and epithelial cells, is crucial for breast cancer growth in the orthotopic microenvironment of the mammary gland. Mice with a hypomorphic allele of...

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PMID: 23593394
DOI: 10.1371/journal.pone.0061071

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