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Autophagy Inhibition by Sustained Overproduction of IL6 Contributes to Arsenic Carcinogenesis

16 May 2014

Abstract excerpt

Chronic inflammation has been implicated as an etiologic factor in cancer, whereas autophagy may help preserve cancer cell survival but exert anti-inflammatory effects. How these phenomenas interact during carcinogenesis remains unclear. We explored this question in a human bronchial epithelial cell-based model of lung carcinogenesis that is mediated by subchronic exposure to arsenic. We found that sustained...

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PMID: 24830721
DOI: 10.1158/0008-5472.can-13-3182

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