Autophagy-Dependent Production of Secreted Factors Facilitates Oncogenic RAS-Driven Invasion

Abstract excerpt

UNLABELLED: The tumor-promoting functions of autophagy are primarily attributed to its ability to promote cancer cell survival. However, emerging evidence suggests that autophagy plays other roles during tumorigenesis. Here, we uncover that autophagy promotes oncogenic RAS-driven invasion. In epithelial cells transformed with oncogenic RAS, depletion of autophagy-related genes suppresses invasion in...

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