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Article

Pathogenic, Total Loss-of-Function DYRK1B Variants Cause Monogenic Obesity Associated With Type 2 Diabetes.

Diabetes care - 1 Mar 2024

Folon Lise, Baron Morgane, Scherrer Victoria, Toussaint Bénédicte, Vaillant Emmanuel, Loiselle Hélène, Dechaume Aurélie, De Pooter Frédérique, Boutry Raphaël, Boissel Mathilde, Diallo Aboubacar, Ning Lijiao, Balkau Beverley, Charpentier Guillaume, Franc Sylvia, Marre Michel, Derhourhi Mehdi, Froguel Philippe, Bonnefond Amélie

Abstract excerpt

OBJECTIVE: Rare variants in DYRK1B have been described in some patients with central obesity, type 2 diabetes, and early-onset coronary disease. Owing to the limited number of conducted studies, the broader impact of DYRK1B variants on a larger scale has yet to be investigated. RESEARCH DESIGN AND METHODS: DYRK1B was sequenced in 9,353 participants from a case-control study for obesity and type 2 diabetes. Each...

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Identifiers

PMID: 38170957
DOI: 10.2337/dc23-1851

Genes

DYRK1B

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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