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Article

Impact of genetic variation in breast cancer resistance protein (BCRP/ABCG2) on sunitinib pharmacokinetics.

Drug metabolism and pharmacokinetics - 1 Jan 2012

Mizuno Tomoyuki, Fukudo Masahide, Terada Tomohiro, Kamba Tomomi, Nakamura Eijiro, Ogawa Osamu, Inui Ken-Ichi, Katsura Toshiya

Abstract excerpt

To elucidate the impact of genetic variations in breast cancer resistance protein (BCRP/ABCG2) and P-glycoprotein (MDR1/ABCB1) on the pharmacokinetics of sunitinib, we carried out a pharmacogenetic study in a clinical setting and pharmacokinetic analysis using Abcg2(-/-), Abcb1a/1b(-/-) and Abcb1a/1b;Abcg2(-/-) mice. Nineteen renal cell carcinoma patients were enrolled in this study. The plasma concentrations of...

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Identifiers

PMID: 22673043
DOI: 10.2133/dmpk.dmpk-12-rg-026

Genes

ABCG2
ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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