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Article

First successful pregnancy in a globozoospermic patient having homozygous mutation in SPATA16.

Fertility and sterility - 1 Jul 2014

Karaca Nilay, Yilmaz Rabiye, Kanten Gulcin E, Kervancioglu Elif, Solakoglu Seyhun, Kervancioglu M Ertan

Abstract excerpt

OBJECTIVE: To report the first case of a successful pregnancy obtained with an infertile 29-year-old man with a homozygous mutation in the spermatogenesis-specific gene SPATA16 after intracytoplasmic sperm injection (ICSI). DESIGN: Case report. SETTING: Assisted reproductive technology (ART) center. PATIENT(S): A couple who suffered from infertility of whom the husband was globozoospermic and carrying a...

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Source

Identifiers

PMID: 24825417
DOI: 10.1016/j.fertnstert.2014.04.002

Genes

SPATA16

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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First successful pregnancy in a globozoospermic patient having homozygous mutation in SPATA16.PMID 24825417Read ↗

Homozygous mutation in SPATA16 is associated with male infertility in human globozoospermia.Semantic proximity Read ↗

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A familial study of twins with severe asthenozoospermia identified a homozygous SPAG17 mutation by whole-exome sequencing.Semantic proximity Read ↗

Homozygous SPAG6 Variants Can Induce Nonsyndromic Asthenoteratozoospermia With Severe MMAFSemantic proximity Read ↗

Human Globozoospermia-Related Gene Spata16 Is Required for Sperm Formation Revealed by CRISPR/Cas9-Mediated Mouse ModelsSemantic proximity Read ↗

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A loss-of-function variant in SSFA2 causes male infertility with globozoospermia and failed oocyte activationSemantic proximity Read ↗

Genetic variation in SPAG16 regions encoding the WD40 repeats is not associated with reduced sperm motility and axonemal defects in a population of infertile males.Semantic proximity Read ↗

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