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Article

Heritability and genetic basis of protein level variation in an outbred population.

Genome research - 1 Aug 2014

Parts Leopold, Liu Yi-Chun, Tekkedil Manu M, Steinmetz Lars M, Caudy Amy A, Fraser Andrew G, Boone Charles, Andrews Brenda J, Rosebrock Adam P

Abstract excerpt

The genetic basis of heritable traits has been studied for decades. Although recent mapping efforts have elucidated genetic determinants of transcript levels, mapping of protein abundance has lagged. Here, we analyze levels of 4084 GFP-tagged yeast proteins in the progeny of a cross between a laboratory and a wild strain using flow cytometry and high-content microscopy. The genotype of trans variants contributed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24823668
DOI: 10.1101/gr.170506.113
PMCID: PMC4120089

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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