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Article

Genetics of single-cell protein abundance variation in large yeast populations.

Nature - 27 Feb 2014

Albert Frank W, Treusch Sebastian, Shockley Arthur H, Bloom Joshua S, Kruglyak Leonid

Abstract excerpt

Variation among individuals arises in part from differences in DNA sequences, but the genetic basis for variation in most traits, including common diseases, remains only partly understood. Many DNA variants influence phenotypes by altering the expression level of one or several genes. The effects of such variants can be detected as expression quantitative trait loci (eQTL). Traditional eQTL mapping requires...

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PMID: 24402228
DOI: 10.1038/nature12904
PMCID: PMC4285441

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