Article
Genetic basis of proteome variation in yeast.
Nature genetics - 1 Nov 2007
Foss Eric J, Radulovic Dragan, Shaffer Scott A, Ruderfer Douglas M, Bedalov Antonio, Goodlett David R, Kruglyak Leonid
Abstract excerpt
Proper regulation of protein levels is essential for health, and abnormal levels of proteins are hallmarks of many diseases. A number of studies have recently shown that messenger RNA levels vary among individuals of a species and that genetic linkage analysis can be used to identify quantitative trait loci that influence these levels. By contrast, little is known about the genetic basis of variation in protein...
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