Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Physiological roles of gonadotropin-inhibitory hormone signaling in the control of mammalian reproductive axis: studies in the NPFF1 receptor null mouse.

Endocrinology - 1 Aug 2014

León Silvia, García-Galiano David, Ruiz-Pino Francisco, Barroso Alexia, Manfredi-Lozano María, Romero-Ruiz Antonio, Roa Juan, Vázquez María J, Gaytan Francisco, Blomenrohr Marion, van Duin Marcel, Pinilla Leonor, Tena-Sempere Manuel

Abstract excerpt

RF-amide-related peptide-3 (RFRP-3), the mammalian ortholog of the avian gonadotropin-inhibiting hormone (GnIH), operates via the NPFF1 receptor (NPFF1R) to repress the reproductive axis, therefore acting as counterpart of the excitatory RF-amide peptide, kisspeptin (ligand of Gpr54). In addition, RFRP-3 modulates feeding and might contribute to the integrative control of energy homeostasis and reproduction. Yet,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Receptors, Neuropeptide
Share to Fasting

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Feedback, Physiological

Share to Gonadotropins

Share to Kisspeptins

Share to Litter Size

Share to Neuropeptides

Share to Sexual Maturation

Source

Identifiers

PMID: 24823392
DOI: 10.1210/en.2014-1030

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Physiological roles of gonadotropin-inhibitory hormone signaling in the control of mammalian reproductive axis: studies in the NPFF1 receptor null mouse.PMID 24823392Read ↗

Dissecting the Roles of Gonadotropin-Inhibitory Hormone in Mammals: Studies Using Pharmacological Tools and Genetically Modified Mouse ModelsSemantic proximity Read ↗

Direct Actions of Kisspeptins on GnRH Neurons Permit Attainment of Fertility but are Insufficient to Fully Preserve Gonadotropic Axis Activity.Semantic proximity Read ↗

Characterization of the inhibitory roles of RFRP3, the mammalian ortholog of GnIH, in the control of gonadotropin secretion in the rat: in vivo and in vitro studiesSemantic proximity Read ↗

RFamide-Related Peptide Neurons Modulate Reproductive Function and Stress Responses.Semantic proximity Read ↗

Development, sex steroid regulation, and phenotypic characterization of RFamide-related peptide (Rfrp) gene expression and RFamide receptors in the mouse hypothalamus.Semantic proximity Read ↗

Origin and Evolution of the Neuroendocrine Control of Reproduction in Vertebrates, With Special Focus on Genome and Gene DuplicationsSemantic proximity Read ↗

Conditional Fgfr1 Deletion in GnRH Neurons Leads to Minor Disruptions in the Reproductive Axis of Male and Female Mice.Semantic proximity Read ↗

GnRH Neuron-Specific Ablation of Gαq/11 Results in Only Partial Inactivation of the Neuroendocrine-Reproductive Axis in Both Male and Female Mice: In Vivo Evidence for Kiss1r-Coupled Gαq/11-Independent GnRH Secretion.Semantic proximity Read ↗

Neuroendocrinology of reproduction: Is gonadotropin-releasing hormone (GnRH) dispensable?Semantic proximity Read ↗

Knockdown of hypothalamic RFRP3 prevents chronic stress-induced infertility and embryo resorptionSemantic proximity Read ↗

How to Contribute to the Progress of Neuroendocrinology: Discovery of GnIH and Progress of GnIH ResearchSemantic proximity Read ↗

Minireview: Genetic Models for the Study of Gonadotropin ActionsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.