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Article

Development, sex steroid regulation, and phenotypic characterization of RFamide-related peptide (Rfrp) gene expression and RFamide receptors in the mouse hypothalamus.

Endocrinology - 1 Apr 2012

Poling Matthew C, Kim Joshua, Dhamija Sangeeta, Kauffman Alexander S

Abstract excerpt

Arginine-phenylalanine-amide (RFamide)-related peptide 3 (RFRP-3, encoded by the Rfrp gene) is the mammalian ortholog of gonadotropin-inhibiting hormone and can inhibit GnRH neuronal activity and LH release. However, the development and regulation of the RFRP-3 system in both sexes is poorly understood. Using in situ hybridization, we examined changes in Rfrp-expressing neurons in mice of both sexes during...

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Identifiers

PMID: 22355072
DOI: 10.1210/en.2011-2049
PMCID: PMC3320244

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BAX

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