Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of PINK1 and DJ-1 confers digenic inheritance of early-onset Parkinson's disease.

Human molecular genetics - 1 Jun 2006

Tang Beisha, Xiong Hui, Sun Ping, Zhang Yuhu, Wang Danling, Hu Zhengmao, Zhu Zanhua, Ma Hong, Pan Qian, Xia Jia-Hui, Xia Kun, Zhang Zhuohua

Abstract excerpt

Mutations in genes encoding both DJ-1 and pten-induced kinase 1 (PINK1) are independently linked to autosomal recessive early-onset familial forms of Parkinson's disease (PD). We here report identification of a family with PD patients harboring novel heterozygous missense mutations in both PINK1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age of Onset
Share to Intracellular Signaling Peptides and Proteins
Share to Mutation, Missense

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Oncogene Proteins

Share to Parkinson Disease

Share to Protein Deglycase DJ-1

Share to Protein Kinases

Share to Sequence Homology, Amino Acid

Source

Identifiers

PMID: 16632486
DOI: 10.1093/hmg/ddl104

Genes

PINK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16632486-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of PINK1 and DJ-1 confers digenic inheritance of early-onset Parkinson's disease.PMID 16632486Read ↗

Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism.Semantic proximity Read ↗

DJ-1: A New Comer in Parkinsons Disease PathologySemantic proximity Read ↗

Association of DJ-1 and parkin mediated by pathogenic DJ-1 mutations and oxidative stress.Semantic proximity Read ↗

Inactivation of <i>Drosophila</i> DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signalingSemantic proximity Read ↗

Hereditary early-onset Parkinson's disease caused by mutations in PINK1.Semantic proximity Read ↗

Characterization of PINK1 (PTEN-induced putative kinase 1) mutations associated with Parkinson disease in mammalian cells and Drosophila.Semantic proximity Read ↗

Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradationSemantic proximity Read ↗

Inactivation of Pink1 Gene in Vivo Sensitizes Dopamine-producing Neurons to 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and Can Be Rescued by Autosomal Recessive Parkinson Disease Genes, Parkin or DJ-1Semantic proximity Read ↗

Clinically reported heterozygous mutations in the PINK1 kinase domain exert a gene dosage effect.Semantic proximity Read ↗

Pink1 Parkinson mutations, the Cdc37/Hsp90 chaperones and Parkin all influence the maturation or subcellular distribution of Pink1.Semantic proximity Read ↗

Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stabilitySemantic proximity Read ↗

Novel P-TEN-induced putative kinase 1 (PINK1) variant in Indian Parkinson's disease patient.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.