Article
Prognostic importance of single-nucleotide polymorphisms in IL-6, IL-10, TGF-β1, IFN-γ, and TNF-α genes in chronic phase chronic myeloid leukemia.
Genetic testing and molecular biomarkers - 1 Jun 2014
Pehlivan Mustafa, Sahin Handan Haydaroglu, Pehlivan Sacide, Ozdilli Kursat, Kaynar Leylagul, Oguz Fatma Savran, Sever Tugce, Yilmaz Mehmet, Eser Bulent, Ogret Yeliz Duvarci, Kis Cem, Okan Vahap, Cetin Mustafa, Carin Mahmut
Abstract excerpt
The aim of this study was to explore the association between polymorphisms of five cytokine genes and clinical parameters in patients with Philadelphia-positive (Ph+) chronic myeloid leukemia (CML) treated with imatinib. We analyzed five cytokine genes (interleukin [IL]-6, IL-10, gamma interferon [IFN-γ], transforming growth factor beta-1 [TGF-β1], and tumor necrosis factor-alpha [TNF-α]) in 60 cases with Ph+ CML...
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