Article
Single nucleotide variants in the protein C pathway and mortality in dialysis patients.
PloS one - 1 Jan 2014
Ocak Gürbey, Drechsler Christiane, Vossen Carla Y, Vos Hans L, Rosendaal Frits R, Reitsma Pieter H, Hoffmann Michael M, März Winfried, Ouwehand Willem H, Krediet Raymond T, Boeschoten Elisabeth W, Dekker Friedo W, Wanner Christoph, Verduijn Marion
Abstract excerpt
BACKGROUND: The protein C pathway plays an important role in the maintenance of endothelial barrier function and in the inflammatory and coagulant processes that are characteristic of patients on dialysis. We investigated whether common single nucleotide variants (SNV) in genes encoding protein C pathway components were associated with all-cause 5 years mortality risk in dialysis patients. METHODS: Single...
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