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Article

CCR5 Deletion Protects Against Inflammation-Associated Mortality in Dialysis Patients

23 Apr 2009

Abstract excerpt

The CC-chemokine receptor 5 (CCR5) is a receptor for various proinflammatory chemokines, and a deletion variant of the CCR5 gene (CCR5 Delta 32) leads to deficiency of the receptor. We hypothesized that CCR5 Delta 32 modulates inflammation-driven mortality in patients with ESRD. We studied the interaction between CCR5 genotype and levels of high-sensitivity C-reactive protein (hsCRP) in 603 incident dialysis...

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PMID: 19389855
DOI: 10.1681/asn.2008040432

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