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Phage-Display-Derived Peptide Binds to Human CD206 and Modeling Reveals a New Binding Site on the Receptor

15 Feb 2019

Abstract excerpt

We recently identified a tumor-homing peptide (mUNO, sequence: “CSPGAK”) that specifically interacts with mouse CD206 to target CD206/MRC1-expressing tumor-associated macrophages in mice. Here, we report studies on the binding of mUNO to human recombinant CD206 (hCD206) and on modeling the mUNO/hCD206 interaction by computational analysis. Fluorescence anisotropy analysis demonstrated that fluorophore-labeled...

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PMID: 30768279
DOI: 10.1021/acs.jpcb.8b11876

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