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Article

Structure-function studies of an engineered scaffold protein derived from Stefin A. II: Development and applications of the SQT variant.

Protein engineering, design & selection : PEDS - 1 Sept 2011

Stadler Lukas Kurt Josef, Hoffmann Toni, Tomlinson Darren Charles, Song Qifeng, Lee Tracy, Busby Michael, Nyathi Yvonne, Gendra Elisenda, Tiede Christian, Flanagan Keith, Cockell Simon J, Wipat Anil, Harwood Colin, Wagner Simon D, Knowles Margaret A, Davis Jason J, Keegan Neil, Ferrigno Paul Ko

Abstract excerpt

Constrained binding peptides (peptide aptamers) may serve as tools to explore protein conformations and disrupt protein-protein interactions. The quality of the protein scaffold, by which the binding peptide is constrained and presented, is of crucial importance. SQT (Stefin A Quadruple Mutant-Tracy) is our most recent development in the Stefin A-derived scaffold series. Stefin A naturally uses three surfaces to...

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Identifiers

PMID: 21616931
DOI: 10.1093/protein/gzr019

Genes

CDK2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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