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Detection of Gene Rearrangements in Targeted Clinical Next-Generation Sequencing

9 May 2014

Abstract excerpt

The identification of recurrent gene rearrangements in the clinical laboratory is the cornerstone for risk stratification and treatment decisions in many malignant tumors. Studies have reported that targeted next-generation sequencing assays have the potential to identify such rearrangements; however, their utility in the clinical laboratory is unknown. We examine the sensitivity and specificity of ALK and KMT2A...

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PMID: 24813172
DOI: 10.1016/j.jmoldx.2014.03.006

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