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Article

Effect of domestication on the spread of the [PIN+] prion in Saccharomyces cerevisiae.

Genetics - 1 Jul 2014

Kelly Amy C, Busby Ben, Wickner Reed B

Abstract excerpt

Prions (infectious proteins) cause fatal neurodegenerative diseases in mammals. In the yeast Saccharomyces cerevisiae, many toxic and lethal variants of the [PSI+] and [URE3] prions have been identified in laboratory strains, although some commonly studied variants do not seem to impair cell growth. Phylogenetic analysis has revealed four major clades of S. cerevisiae that share histories of two prion proteins...

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Identifiers

PMID: 24812307
DOI: 10.1534/genetics.114.165670
PMCID: PMC4096356

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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