Article
A systematic survey identifies prions and illuminates sequence features of prionogenic proteins.
Cell - 3 Apr 2009
Alberti Simon, Halfmann Randal, King Oliver, Kapila Atul, Lindquist Susan
Abstract excerpt
Prions are proteins that convert between structurally and functionally distinct states, one or more of which is transmissible. In yeast, this ability allows them to act as non-Mendelian elements of phenotypic inheritance. To further our understanding of prion biology, we conducted a bioinformatic proteome-wide survey for prionogenic proteins in S. cerevisiae, followed by experimental investigations of 100 prion...
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