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Article

DICER1 is essential for survival of postmitotic rod photoreceptor cells in mice

8 May 2014

Abstract excerpt

Photoreceptor cell death is the proximal cause of blindness in many retinal degenerative disorders; hence, understanding the gene regulatory networks that promote photoreceptor survival is at the forefront of efforts to combat blindness. Down-regulation of the microRNA (miRNA)-processing enzyme DICER1 in the retinal pigmented epithelium has been implicated in geographic atrophy, an advanced form of age-related...

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PMID: 24812086
DOI: 10.1096/fj.14-254292

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