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Article

Whole-genome studies identify solute carrier transporters in cellular susceptibility to paclitaxel.

Pharmacogenetics and genomics - 1 Jul 2012

Njiaju Uchenna O, Gamazon Eric R, Gorsic Lidija K, Delaney Shannon M, Wheeler Heather E, Im Hae Kyung, Dolan M Eileen

Abstract excerpt

OBJECTIVE: The clinical use of paclitaxel is limited by variable responses and the potential for significant toxicity. To date, studies of associations between variants in candidate genes and paclitaxel effects have yielded conflicting results. We aimed to evaluate the relationships between global gene expression and paclitaxel sensitivity. METHODS: We utilized well-genotyped lymphoblastoid cell lines derived...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22437668
DOI: 10.1097/FPC.0b013e328352f436
PMCID: PMC3376193

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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