Article
ABCB1 (MDR1) polymorphisms and ovarian cancer progression and survival: a comprehensive analysis from the Ovarian Cancer Association Consortium and The Cancer Genome Atlas.
Gynecologic oncology - 1 Oct 2013
Johnatty Sharon E, Beesley Jonathan, Gao Bo, Chen Xiaoqing, Lu Yi, Law Matthew H, Henderson Michelle J, Russell Amanda J, Hedditch Ellen L, Emmanuel Catherine, Fereday Sian, Webb Penelope M, Goode Ellen L, Vierkant Robert A, Fridley Brooke L, Cunningham Julie M, Fasching Peter A, Beckmann Matthias W, Ekici Arif B, Hogdall Estrid, Kjaer Susanne K, Jensen Allan, Hogdall Claus, Brown Robert, Paul Jim, Lambrechts Sandrina, Despierre Evelyn, Vergote Ignace, Lester Jenny, Karlan Beth Y, Heitz Florian, du Bois Andreas, Harter Philipp, Schwaab Ira, Bean Yukie, Pejovic Tanja, Levine Douglas A, Goodman Marc T, Camey Michael E, Thompson Pamela J, Lurie Galina, Shildkraut Joellen, Berchuck Andrew, Terry Kathryn L, Cramer Daniel W, Norris Murray D, Haber Michelle, MacGregor Stuart, deFazio Anna, Chenevix-Trench Georgia
Abstract excerpt
OBJECTIVE: ABCB1 encodes the multi-drug efflux pump P-glycoprotein (P-gp) and has been implicated in multi-drug resistance. We comprehensively evaluated this gene and flanking regions for an association with clinical outcome in epithelial ovarian cancer (EOC). METHODS: The best candidates from fi...
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