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Article

Impact of ABCB1 variants on neutrophil depression: a pharmacogenomic study of paclitaxel in 92 women with ovarian cancer.

Basic & clinical pharmacology & toxicology - 1 Feb 2012

Bergmann Troels K, Brasch-Andersen Charlotte, Gréen Henrik, Mirza Mansoor R, Skougaard Kristin, Wihl Jessica, Keldsen Nina, Damkier Per, Peterson Curt, Vach Werner, Brøsen Kim

Abstract excerpt

The standard treatment for ovarian cancer in advanced stages is post-surgery treatment with taxane-platin chemotherapy. Despite an initial high response rate, most patients eventually relapse. The dose-limiting toxicities of paclitaxel are neutropenia and neuropathy, but the inter-individual variability is large. The aim of this prospective study was to investigate the impact of genetic variants in key drug...

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Share to Aryl Hydrocarbon Hydroxylases
Share to ATP Binding Cassette Transporter, Subfamily B

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP2C8

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Source

Identifiers

PMID: 21955855
DOI: 10.1111/j.1742-7843.2011.00802.x

Genes

ABCB1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Impact of ABCB1 variants on neutrophil depression: a pharmacogenomic study of paclitaxel in 92 women with ovarian cancer.PMID 21955855Read ↗

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