Article
Relationship between obesity and the risk of clinically significant depression: Mendelian randomisation study.
The British journal of psychiatry : the journal of mental science - 1 Jul 2014
Hung Chi-Fa, Rivera Margarita, Craddock Nick, Owen Michael J, Gill Michael, Korszun Ania, Maier Wolfgang, Mors Ole, Preisig Martin, Rice John P, Rietschel Marcella, Jones Lisa, Middleton Lefkos, Aitchison Kathy J, Davis Oliver S P, Breen Gerome, Lewis Cathryn, Farmer Anne, McGuffin Peter
Abstract excerpt
BACKGROUND: Obesity has been shown to be associated with depression and it has been suggested that higher body mass index (BMI) increases the risk of depression and other common mental disorders. However, the causal relationship remains unclear and Mendelian randomisation, a form of instrumental variable analysis, has recently been employed to attempt to resolve this issue. AIMS: To investigate whether higher BMI...
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