Article
Body mass index and depressive symptoms: instrumental-variables regression with genetic risk score.
Genes, brain, and behavior - 1 Nov 2012
Jokela M, Elovainio M, Keltikangas-Järvinen L, Batty G D, Hintsanen M, Seppälä I, Kähönen M, Viikari J S, Raitakari O T, Lehtimäki T, Kivimäki M
Abstract excerpt
The causal role of obesity in the development of depression remains uncertain. We applied instrumental-variables regression (Mendelian randomization) to examine the association of adolescent and adult body mass index (BMI) with adult depressive symptoms. Participants were from the Young Finns prospective cohort study (n = 1731 persons, 2844 person-observations), with repeated measurements of BMI and depressive...
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