Chromosome cohesion decreases in human eggs with advanced maternal age

Abstract excerpt

Aneuploidy in human eggs increases with maternal age and can result in infertility, miscarriages, and birth defects. The molecular mechanisms leading to aneuploidy, however, are largely unknown especially in the human where eggs are exceedingly rare and precious. We obtained human eggs from subjects ranging from 16.4 to 49.7 years old following in vitro maturation of oocyte-cumulus complexes isolated directly...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Prenatal Screening and Diagnostics
• Share to Renal and related cancers
• Share to Reproductive Biology and Fertility