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Article

Vasoactive intestinal peptide maintains the nonpathogenic profile of human th17-polarized cells.

Journal of molecular neuroscience : MN - 1 Nov 2014

Jimeno Rebeca, Leceta Javier, Martínez Carmen, Gutiérrez-Cañas Irene, Carrión Mar, Pérez-García Selene, Garín Marina, Mellado Mario, Gomariz Rosa P, Juarranz Yasmina

Abstract excerpt

The cytokine microenvironment modulates CD4 T cell differentiation causing the shift of naïve CD4 T cells into different cell subsets. This process is also regulated by modulators such as vasoactive intestinal peptide (VIP), a neuropeptide with known immunomodulatory properties on CD4 T cells that exert this action through specific receptors, vasoactive intestinal peptide receptor (VPAC)1 and VPAC2. Our results...

Read the complete abstract on PubMed

Topics

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Share to Cytotoxicity, Immunologic
Share to Interleukin-17

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Nuclear Receptor Subfamily 1, Group F, Member 1

Share to Nuclear Receptor Subfamily 1, Group F, Member 3

Share to Receptors, Interleukin

Share to STAT3 Transcription Factor

Share to Th17 Cells

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Source

Identifiers

PMID: 24805298
DOI: 10.1007/s12031-014-0318-3

Genes

VIP
RORA
RORC
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Vasoactive intestinal peptide maintains the nonpathogenic profile of human th17-polarized cells.PMID 24805298Read ↗

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