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Article

A natural variant type II G protein-coupled receptor for vasoactive intestinal peptide with altered function.

The Journal of biological chemistry - 24 Sept 2004

Grinninger Carola, Wang Wengang, Oskoui Kaveh Bastani, Voice Julia K, Goetzl Edward J

Abstract excerpt

The vasoactive intestinal peptide (VIP) and its G protein-coupled receptors VPAC1 and VPAC2 prominently mediate diverse physiological functions in the neural, endocrine, and immune systems. A deletion variant of mouse VPAC2 has been identified in immune cells that lacks amino acids 367-380 at the carboxyl-terminal end of the seventh transmembrane domain. When expressed at equivalent levels in a human Jurkat T...

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Identifiers

PMID: 15302876
DOI: 10.1074/jbc.C400332200

Genes

VIP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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A natural variant type II G protein-coupled receptor for vasoactive intestinal peptide with altered function.PMID 15302876Read ↗

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Finding functional gaps: integrative analysis of VPAC1- and VPAC2-mediated signalling pathways in human lymphocytesSemantic proximity Read ↗

Mutational analysis of the human vasoactive intestinal peptide receptor subtype VPAC(2): role of basic residues in the second transmembrane helix.Semantic proximity Read ↗

Recent advances in vasoactive intestinal peptide physiology and pathophysiology: focus on the gastrointestinal systemSemantic proximity Read ↗

Effect of inactivating mutations on phosphorylation and internalization of the human VPAC2 receptor.Semantic proximity Read ↗

Vasoactive intestinal peptide maintains the nonpathogenic profile of human th17-polarized cells.Semantic proximity Read ↗

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The human vasoactive intestinal Peptide/Pituitary adenylate cyclase activating peptide receptor 1 (VPAC1): constitutive activation by mutations at threonine 343.Semantic proximity Read ↗

Identification of the early VIP-regulated transcriptome and its associated, interactome in resting and activated murine CD4 T cells.Semantic proximity Read ↗

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