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Article

Th17 polarization of memory Th cells in early arthritis: the vasoactive intestinal peptide effect

8 May 2015

Abstract excerpt

Several studies in humans indicate the implication of Th17 cells in RA. Therapies targeting their pathogenicity, as well as their plasticity to the Th17/1 phenotype, could ameliorate the progression of the pathology. The neuroendocrine environment has a major impact on the differentiation of lymphoid cells. VIP is present in the microenvironment of the joint, and its known therapeutic effects are supported by...

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PMID: 25957307
DOI: 10.1189/jlb.3a0714-327r

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