Article
NRAS mutations are more prevalent than KIT mutations in melanoma of the female urogenital tract--a study of 24 cases from the Netherlands.
Gynecologic oncology - 1 Jul 2014
van Engen-van Grunsven Adriana C H, Küsters-Vandevelde Heidi V N, De Hullu Joanne, van Duijn Lucette M, Rijntjes Jos, Bovée Judith V M G, Groenen Patricia J T A, Blokx Willeke A M
Abstract excerpt
OBJECTIVE: The aim of this study was to evaluate a series of primary melanomas of the female urogenital tract for oncogenic mutations in KIT, NRAS and BRAF in order to identify patients who may be amenable to targeted therapy. METHODS: We reviewed twenty-four cases of female urogenital tract melanomas and used Sanger sequencing analysis for the detection of oncogenic mutations in exons 9, 11, 13, and 17 of KIT;...
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