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Article

KIT pathway alterations in mucosal melanomas of the vulva and other sites.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jun 2011

Omholt Katarina, Grafström Eva, Kanter-Lewensohn Lena, Hansson Johan, Ragnarsson-Olding Boel K

Abstract excerpt

PURPOSE: A significant proportion of mucosal melanomas contain alterations in KIT. The aim of this study was to characterize the pattern of KIT, NRAS, and BRAF mutations in mucosal melanomas at specific sites and to assess activation of the KIT downstream RAF/MEK/extracellular signal-regulated kinase (ERK) and phosphoinositide 3-kinase (PI3K)/AKT pathways in mucosal melanoma specimens. EXPERIMENTAL DESIGN:...

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Share to Extracellular Signal-Regulated MAP Kinases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins c-akt

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Source

Identifiers

PMID: 21680547
DOI: 10.1158/1078-0432.CCR-10-2917

Genes

KIT
NRAS
BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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