Article

Recurrent KRAS Mutation and Co-mutation of KIT and SF3B1 in Melanoma of the Female Genital Tract

2021-02-19

Abstract excerpt

<h4>Background: </h4> Malignant melanoma of the female genital tract is relatively uncommon and accounts for 5% of all melanomas in women. This study aimed to identify driver genes in melanoma of the female genital tract with the purpose of enhancing understanding of disease pathogenesis and identifying potential new therapeutic targets to develop effective therapies. <h4>Methods: </h4> KIT (CD117) and BRAF expres...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 20d3c638-e997-51ac-8c46-2bf0a1ce08cf
DOI: 10.21203/rs.3.rs-200381/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Recurrent KRAS Mutation and Co-mutation of KIT and SF3B1 in Melanoma of the Female Genital TractDOI 10.21203/rs.3.rs-200381/v1Read

Recurrent KRAS, KIT and SF3B1 mutations in melanoma of the female genital tract.Semantic proximity Read

Oncogenic mutations in melanomas and benign melanocytic nevi of the female genital tract.Semantic proximity Read

Molecular Alterations in Vaginal Melanomas: Report of 4 Cases and Literature Review.Semantic proximity Read

Malignant Melanoma of Vulva and VaginaSemantic proximity Read

Gynecologic melanomas: A clinicopathologic and molecular analysis.Semantic proximity Read

Female genitourinary tract melanoma: mutation analysis with clinicopathologic correlation: a single-institution experience.Semantic proximity Read

Vulvar and vaginal melanoma: A unique subclass of mucosal melanoma based on a comprehensive molecular analysis of 51 cases compared with 2253 cases of nongynecologic melanoma.Semantic proximity Read

Prevalence of NRAS Mutation, PD-L1 Expression and Amplification, and Overall Survival Analysis in 36 Primary Vaginal Melanomas.Semantic proximity Read

NRAS mutations are more prevalent than KIT mutations in melanoma of the female urogenital tract--a study of 24 cases from the Netherlands.Semantic proximity Read

Vaginal melanoma in Denmark from 1980 to 2018: A population-based study based on genetic profile and survival.Semantic proximity Read

Low mutational burden of eight genes involved in the MAPK/ERK, PI3K/AKT, and GNAQ/11 pathways in female genital tract primary melanomas.Semantic proximity Read

Whole-exome sequencing identifies recurrent SF3B1 R625 mutation and comutation of NF1 and KIT in mucosal melanoma.Semantic proximity Read