Article
Adaptively weighted association statistics.
Genetic epidemiology - 1 Jul 2009
LeBlanc Michael, Kooperberg Charles
Abstract excerpt
We investigate methods for testing gene-disease outcome associations in situations where the genetic relationship potentially varies among subjects with differing environmental or clinical attributes. We propose a strategy which modestly increases multiple testing by evaluating weighted test statistics which focus (or enrich) association tests within subgroups and use a Monte-Carlo method, based on simulating...
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