Article

Bacterial protein domains with a novel Ig-like fold target human CEACAM receptors

2020-06-10

Abstract excerpt

Streptococcus agalactiae , also known as group B Streptococcus (GBS), is the major cause of neonatal sepsis in humans. A critical step to infection is adhesion of bacteria at mucosal surfaces. Though several GBS adhesins have been identified, the host receptor targets of these adhesins remain unknown. We report here that surface-expressed β protein from GBS binds to human CEACAM1 and CEACAM5 receptors. A crystal...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 753c4ece-07f2-589b-96d5-64009474c0d0
DOI: 10.1101/2020.06.09.141622

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Bacterial protein domains with a novel Ig-like fold target human CEACAM receptorsDOI 10.1101/2020.06.09.141622Read

Bacterial protein domains with a novel Ig‐like fold target human CEACAM receptorsSemantic proximity Read

Human CEACAM1 is targeted by a Streptococcus pyogenes adhesin implicated in puerperal sepsis pathogenesisSemantic proximity Read

The <i>Streptococcus agalactiae</i> R3 surface protein is encoded by <i>sar5</i>Semantic proximity Read

Structural and Functional Analysis of Cell Wall-anchored Polypeptide Adhesin BspA in Streptococcus agalactiaeSemantic proximity Read

FbsC, a Novel Fibrinogen-binding Protein, Promotes Streptococcus agalactiae-Host Cell InteractionsSemantic proximity Read

CEACAM1 recognition by bacterial pathogens is species-specificSemantic proximity Read

The Multifaceted Nature of Streptococcal Antigen I/II Proteins in Colonization and Disease PathogenesisSemantic proximity Read

Streptococcal Adhesin P (SadP) contributes to Streptococcus suis adhesion to the human intestinal epitheliumSemantic proximity Read

CEACAM3: An innate immune receptor directed against human-restricted bacterial pathogensSemantic proximity Read

A CRISPRi Library Screen in Group B <i>Streptococcus</i> Identifies Surface Immunogenic Protein (Sip) as a Mediator of Multiple Host InteractionsSemantic proximity Read

Identification of a novel streptococcal adhesin P (SadP) protein recognizing galactosyl-α1-4-galactose-containing glycoconjugates: convergent evolution of bacterial pathogens to binding of the same host receptor.Semantic proximity Read

BibA: a novel immunogenic bacterial adhesin contributing to group B <i>Streptococcus</i> survival in human bloodSemantic proximity Read