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Article

Group B Streptococcus suppression of phagocyte functions by protein-mediated engagement of human Siglec-5.

The Journal of experimental medicine - 3 Aug 2009

Carlin Aaron F, Chang Yung-Chi, Areschoug Thomas, Lindahl Gunnar, Hurtado-Ziola Nancy, King Charles C, Varki Ajit, Nizet Victor

Abstract excerpt

Group B Streptococcus (GBS) is a leading cause of invasive bacterial infections in human newborns. A key GBS virulence factor is its capsular polysaccharide (CPS), displaying terminal sialic acid (Sia) residues which block deposition and activation of complement on the bacterial surface. We recently demonstrated that GBS Sia can bind human CD33-related Sia-recognizing immunoglobulin (Ig) superfamily lectins...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19596804
DOI: 10.1084/jem.20090691
PMCID: PMC2722167

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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