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Article

Human-specific expression of Siglec-6 in the placenta

18 Apr 2007

Abstract excerpt

CD33-related-Siglecs are lectins on immune cells that recognize sialic acids via extracellular domains, and deliver negative signals via cytosolic tyrosine-based regulatory motifs. We report that while Siglec-6/OB-BP1 (which can also bind leptin) is expressed on immune cells of both humans and the closely related great apes, placental trophoblast expression is human-specific, with little or no expression in ape...

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PMID: 17580316
DOI: 10.1093/glycob/cwm065

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