Article

Influence of CYP2C19 and ABCB1 Genetic Polymorphisms on Clopidogrel Pharmacokinetics: A PharmGKB Retrospective Analysis

2025-07-07

Abstract excerpt

<h4>Background: </h4> Clopidogrel, an antiplatelet prodrug widely prescribed for thrombotic risk reduction in cardiovascular patients, shows marked interindividual response variability due to genetic polymorphisms in CYP2C19 and ABCB1. <h4>Objectives:</h4> To determine the impact of key polymorphisms (CYP2C19 *2, *3 and ABCB1 3435C>T) on pharmacokinetic parameters and adherence outcomes, using curated PharmGKB...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 71d1265b-86ae-5ceb-af6e-aa9c75dad494
DOI: 10.20944/preprints202507.0576.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Influence of CYP2C19 and ABCB1 Genetic Polymorphisms on Clopidogrel Pharmacokinetics: A PharmGKB Retrospective AnalysisDOI 10.20944/preprints202507.0576.v1Read

Clinical Pharmacogenetics Implementation Consortium guidelines for CYP2C19 genotype and clopidogrel therapy: 2013 update.Semantic proximity Read

Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450-2C19 (CYP2C19) genotype and clopidogrel therapy.Semantic proximity Read

CYP2C19 genotype testing for clopidogrel: A guideline developed by the UK Centre of Excellence in Regulatory Science and Innovation in Pharmacogenomics (CERSI-PGx).Semantic proximity Read

CYP2C19 genotype-guided antiplatelet therapy: promises and pitfalls.Semantic proximity Read

Genotyping genetic variants of CYP2C19 for precision antiplatelet dosing: state of the art and future perspectives.Semantic proximity Read

Pharmacogenetics of clopidogrel.Semantic proximity Read

Clopidogrel pharmacogenetics: metabolism and drug interactions.Semantic proximity Read

Cardiovascular Pharmacogenomics: An Update on Clinical Studies of Antithrombotic Drugs in Brazilian Patients.Semantic proximity Read

Cytochrome P450 genotype-guided drug therapies: An update on current states.Semantic proximity Read

Pharmacogenetics of Antiplatelets and Anticoagulants: A Report on Clopidogrel, Warfarin and DabigatranSemantic proximity Read

Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2C19 Genotype and Clopidogrel Therapy: 2022 Update.Semantic proximity Read

Can CYP2C19 genotyping improve antiplatelet therapy efficacy in real-life practice? Recent advances.Semantic proximity Read