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Article

Short-term stimulation of calcium-permeable transient receptor potential canonical 5-containing channels by oxidized phospholipids.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jul 2010

Al-Shawaf Eman, Naylor Jacqueline, Taylor Hilary, Riches Kirsten, Milligan Carol J, O'Regan David, Porter Karen E, Li Jing, Beech David J

Abstract excerpt

OBJECTIVE: To determine whether calcium-permeable channels are targets for the oxidized phospholipids: 1-palmitoyl-2-glutaroyl-phosphatidylcholine (PGPC) and 1-palmitoyl-2-oxovaleroyl-phosphatidylcholine (POVPC). METHODS AND RESULTS: Oxidized phospholipids are key factors in inflammation and associated diseases, including atherosclerosis; however, the initial reception mechanisms for cellular responses to the...

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Topics

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Share to Calcium Signaling
Share to GTP-Binding Protein alpha Subunits, Gi-Go

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Membrane Potentials

Share to Muscle, Smooth, Vascular

Share to Myocytes, Smooth Muscle

Share to Oxidation-Reduction

Share to TRPC Cation Channels

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Source

Open in PubMed Open full text

Identifiers

PMID: 20378846
DOI: 10.1161/ATVBAHA.110.205666
PMCID: PMC2887788

Genes

TRPC5
TRPC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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