Reduced mitochondrial DNA content and heterozygous nuclear gene mutations in patients with acute liver failure.

Abstract excerpt

OBJECTIVES: Historically, mitochondrial disorders have been associated with predominantly multisystem or neurological symptoms. If present, hepatic complications were thought to be a late feature. Recently, mutations in at least 4 nuclear genes have been identified in infants presenting with rapidly progressive hepatic failure, which may be precipitated by infection or drugs. We aimed to determine whether hepatic...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cell Nucleus
• Share to DNA, Mitochondrial