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Article

Phorbol myristate acetate, but not CD40L, induces the differentiation of CLL B cells into Ab-secreting cells.

Immunology and cell biology - 1 Aug 2014

Ghamlouch Hussein, Ouled-Haddou Hakim, Guyart Aude, Regnier Aline, Trudel Stéphanie, Claisse Jean-François, Fuentes Vincent, Royer Bruno, Marolleau Jean-Pierre, Gubler Brigitte

Abstract excerpt

In this study, we investigated the capacity of chronic lymphocytic leukemia (CLL) B cells to undergo terminal differentiation into Ig-secreting plasma cells in T cell-independent and T cell-dependent responses. We used a two-step model involving stimulation with phorbol myristate acetate (PMA) and CD40L, together with cytokines (PMA/c and CD40L/c), for 7 days. We describe immunophenotypic modifications, changes...

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Identifiers

PMID: 24797583
DOI: 10.1038/icb.2014.37
PMCID: PMC4134517

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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