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Article

Terminal differentiation into plasma cells initiates the replicative cycle of Epstein-Barr virus in vivo.

Journal of virology - 1 Jan 2005

Laichalk Lauri L, Thorley-Lawson David A

Abstract excerpt

In this paper we demonstrate that the cells which initiate replication of Epstein-Barr virus (EBV) in the tonsils of healthy carriers are plasma cells (CD38hi, CD10-, CD19+, CD20lo, surface immunoglobulin negative, and cytoplasmic immunoglobulin positive). We further conclude that differentiation into plasma cells, and not the signals that induce differentiation, initiates viral replication. This was confirmed by...

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Source

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Identifiers

PMID: 15613356
DOI: 10.1128/JVI.79.2.1296-1307.2005
PMCID: PMC538585

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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